I-CLOR

To help reduce the incidence of tying up by reducing the build-up of lactic acid in muscle cells.

I-CLOR contains Dichloroacetic acid, which is activator of the enzyme pyruvate dehydrogenase. This enzyme plays a central role in the process of lactic acid production during hard work. Supplementation with Dichloroacetic acid (DCA) results in activation of the enzyme pyruvate dehydrogenase, leading to a reduction in the rate of lactic acid production and accumulation in muscles. Elevated plasma lactate levels result in a reduction in pH which contributes to muscle fatigue and decreased muscle performance. The pathogenesis of Exertional Rhabdomyolysis in Horses are related to lactic acidosis during exercise, and associated low muscle pH. Sodium bicarbonate and Dimethylglycine (DMG), which may help to reduce lactic acid accumulation during exercise, have been used to assist in the prevention of tying up in Horses. Similarly, DCA (I-CLOR) results in reduction in the rate of lactate accumulation, and a delay in the onset of muscle fatigue.

Give 20 - 40 ml by Intravenous Injection (diluted in 1 Litre saline, or administer via catheter). Administer once weekly for 4 weeks then discontinue for 4 weeks before repeating the course.