D-CLOR

DICHLORO ACETIC ACID INJECTION

D-CLOR helps reduce the incidence of tying up by reducing the build-up of lactic acid in muscle cells.

WHO GMP Accredited Company

Category

Veterinary Medicines, Liquid Injections

Pack Size

100 ml

Horses

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COMPOSITION

Each ml contains :

Dichloro-acetic acid

120 mcg

Sodium gluconate

USP 250 mg

Water for Injection

B.P. q.s

INDICATION

To help reduce the incidence of tying up by reducing the build-up of lactic acid in muscle cells.

ACTIONS

D-CLOR contains Dichloroacetic acid, which is activator of the enzyme pyruvate dehydrogenase. This enzyme plays a central role in the process of lactic acid production during hard work. Supplementation with Dichloroacetic acid (DCA) results in activation of the enzyme pyruvate dehydrogenase, leading to a reduction in the rate if lactic acid production and accumulation in muscles. Elevated plasma lactate levels result in a reduction in pH which contributes to muscle fatigue and decreased muscle performance. The pathogenesis of Exertional Rhabdomyolysis in Horses is related to lactic acidosis during exercise, and associated low muscle pH. Sodium bicarbonate and Dimethylglycine (DMG), which may help to reduce lactic acid accumulation during exercise have been used to assist in the prevention of tying up in Horses. Similarly, DCA (D-CLOR) results in reduction in the rate of lactate accumulation, and a delay in the onset of muscle fatigue.

WARNING

Take care to avoid leakage from the vein. D-CLOR is highly irritant if given outside the vein. Avoid accidental contact with mucous membranes or eyes (avoid accidental spillage or spray).

PRECAUTION

This product does not contain any antimicrobial preservative. Any solution remaining in the vial after following withdrawal of required dose should be discarded.

DOSAGE AND ADMINISTRATION

Give 20-40 ml by Intravenous Injection (diluted in 1 litre saline or administer via catheter). Administer once weekly for 4 weeks then discontinue for 4 weeks before repeating the course.

WITHDRAWAL PERIOD

Nil